This consensus statement reviews the metabolism of triglyceride-rich lipoproteins, the epidemiology of chylomicronemia, and clinical and diagnostic differences between familial chylomicronemia syndrome (FCS) and multifactorial chylomicronemia syndrome (MCS), and presents the rationale for a new diagnostic approach and shift in paradigm for defining adults with persistent chylomicronemia (PC) along with alarm features for risk stratification and recommendations on management options.

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