Educational Modules

In this introductory module, participants will gain a clear understanding of the underlying mechanisms that drive hypertriglyceridemia. Learners will explore:

• How triglycerides are normally synthesized, transported, and metabolized in the body
• The role of lipoproteins, enzymes (e.g., LPL, ApoC-III), and hormonal regulation in triglyceride balance
• Genetic and acquired factors that lead to elevated triglycerides
• The pathophysiologic link between severe HTG and complications such as pancreatitis and increased cardiovascular risk

By the end of this module, participants will be able to explain the key pathways involved in triglyceride metabolism, recognize the mechanisms that contribute to dysregulation, and set the foundation for evaluating and treating patients with elevated triglycerides.

In Module #2, participants will gain a clear understanding of the clinical significance and management of chylomicronemia in the setting of severe hypertriglyceridemia. Learners will explore:

• The relationship between severe hypertriglyceridemia, chylomicronemia, and a markedly increased risk of acute pancreatitis
• The clinical presentation and pathophysiology of chylomicronemia, including the definitions of genetic FCS, clinical FCS, and persistent chylomicronemia
• Dietary and lifestyle counseling strategies and foundational pharmacotherapy for the management of chylomicronemia
• The role of newly approved apo C-III inhibitors as advanced therapy for the prevention of acute pancreatitis in chylomicronemia

By the end of this module, participants will be able to recognize high-risk chylomicronemia, differentiate emerging clinical phenotypes, implement evidence-based lifestyle and pharmacologic interventions, and determine when to escalate care with apoC-III inhibitors to reduce the risk of acute pancreatitis.